Improving selectivity of ion-sensitive membrane by polyethylene glycol doping

Hydrophobic ions can generate considerable interference to ion detection in a complex analyte with membrane-based ion-selective sensors, due the hydrophobic interaction. In this paper, we demonstrate that from interaction sensors be significantly reduced by incorporating hydrophilic polyethylene glycol (PEG) into membrane. The sensor is silicon nanowire field-effect transistor (SiNWFET) its surface functionalized an ionophore-doped mixed-matrix membrane (MMM), where ionophore either commercial Na-ionophore ? or novel synthetic metal-organic supercontainer. incorporation of PEG suppresses partitioning MMM and thus reduces their target ions. This evidenced improvement selectivity for Na+ presence interfering methylene blue (MB+) more than order magnitude. It further enables MB+ using SiNWFET array multiplexed manner controlled susceptivity cross-interference greatly expanded dynamic range.